Sona’s Cancer Therapy Creates a Systemic Immune Response in Murine Breast Cancer Model
Halifax, Nova Scotia — (Newsfile Corp. – April 29, 2024) – Sona Nanotech Inc. (CSE: SONA) (OTCQB: SNANF) (the “Company” or “Sona”) announces further results from the triple negative breast cancer murine model portion of its current research study at Dalhousie University (the “Study”) which confirms that the previously reported tumor volume reduction was due to activation of a tumor specific systemic immune response. These data relate to the follow-up biomarker analysis performed on the previously reported cohort of animals that showed a statistically significant synergistic effect in the shrinking of both treated and untreated tumors in animals bearing multiple tumors after treatment with the combination of Sona’s targeted hyperthermia therapy (“THT”) and interleukin-2 (“IL-2”), an immunotherapy agent widely used to treat human cancer patients.
The fluorescence-activated cell sorting (“FACS”) analysis of the tumor infiltrating cells looking at two panels of 12 biomarkers demonstrated a statistically significant cytotoxic T-cell infiltrate in both treated tumors and the untreated (contralateral) tumors, confirming a systemic immune response, consistent with an abscopal effect, in the treated mice treated with the combined THT and IL-2 therapy that is not seen in the other groups. Also notable is the fact that cytotoxic T-cells in treated tumors express significantly more immune checkpoint indicating potential for additional benefits.
